How to pronounce vaccine in American English
vak·SEEN
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Americans pronounce vaccine as vak-SEEN (/vækˈsin/). Stress falls on the second syllable — keep everything else short and quick.
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Watch out
Common pronunciation mistakes in American English.
The textbook way isn't wrong — it's just not how anyone actually says it.
01
Stressing the wrong syllable.
Stress falls on the second syllable, not the others. Stretch SEEN — keep everything else short and quick.
VAK·seen→vak·SEEN
Questions
Questions people ask about this.
How is "vaccine" stressed in American English?
Stress falls on the second syllable — say "SEEN" with a longer, fuller vowel and keep every other syllable short and quick. The respell "vak-SEEN" marks the stressed syllable in capitals so the rhythm is easy to read at a glance.
Is the American pronunciation of "vaccine" different from British English?
American English uses different vowel shapes, a relaxed retroflex R, and connected-speech tricks like flap-T and glottal-stop T that British Received Pronunciation generally avoids. The respell "vak-SEEN" reflects the casual American form; British dictionaries typically print a citation form with crisper consonants and different vowel choices.
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