Press your lips together. Air flows through your nose. Vocal cords vibrate.

Americans pronounce mitochondrion as mahy-tuh-KAHN-dree-uhn (/ˌmaɪɾəˈkɑndriən/). In "mitochondrion", the "t" between vowels sounds like a quick "d" — the tongue briefly taps the ridge behind the upper teeth. This is called the Flap T, a small move that separates 'classroom' from 'native'. So instead of mahy·tuh·KAHN·tree·uhn, you get MAHY·tuh·KAHN·dree·uhn. Stress falls on the third syllable — keep everything else short and quick. You'll hear it in sentences like "The mitochondrion is known as the powerhouse of the cell".
Record yourself saying "mitochondrion" and play it back. The mic stays on your device — nothing's uploaded.
5 syllables, 12 sounds. Tap a syllable to jump to its row, then explore each sound's mouth shape and how it's made.
Raise the back of your tongue to touch the soft palate (velum). Stop the air, then release.

Relax your lips and drop your jaw significantly. The tongue tip lightly touches behind the bottom front teeth and the back part of the tongue presses down a little to create more dark space in the back of the mouth.

Touch the tip or front edge of your tongue to the roof of your mouth behind your teeth. Air flows through your nose.

Tongue pulls back slightly from the D position, blending into R. Sounds close to 'jr'.

Curl or bunch your tongue without letting the tip touch the roof of your mouth. Brace the sides of your tongue against your upper back teeth, and round your lips slightly.
Pull the corners of your lips back slightly. Arch the middle-front of your tongue high toward the roof of the mouth.

The textbook way isn't wrong — it's just not how anyone actually says it.
In "mitochondrion", the "t" between vowels sounds like a quick "d" — the tongue briefly taps the ridge behind the upper teeth. /t/ or /d/ becomes a quick tap [ɾ] — sounds like a soft D. The tongue briefly taps the ridge behind the upper teeth.
In "mitochondrion", the "dr" cluster blends into a "jr" sound — a natural American English pronunciation. /d/ shifts toward /dʒ/ ("j"), so DR sounds like "jr".
In "mitochondrion", the short unstressed vowel before "n" disappears — the schwa is absorbed and the "n" becomes the syllable nucleus on its own. Schwa is absorbed — consonant becomes the syllable nucleus.
Stress falls on the third syllable, not the others. Stretch KAHN — keep everything else short and quick.